New chemical access for pyran core embedded derivatives from bisalkenylated 1,3-diketones and 1,3-diketoesters via tandem C-dealkenylation and cyclization

作者：Narender T^*; Sarkar S; Venkateswarlu K; Kumar J K

来源：Tetrahedron Letters, 2010, 51(50): 6576-6579.

DOI：10.1016/j.tetlet.2010.10.030

• 1,3-Diketone
• 1,3-Diketoester
• 3,4-Dihydro-2H-pyrans
• AlCl(3)

New chemical access has been developed for the synthesis of pyran core embedded derivatives from 1,3-diketones and 1,3-diketoesters, in which the active methylene group of 1,3-diketone or 1,3-diketoester was alkenylated with three equivalents of alkenyl bromides in presence NaH to give bisalkenyl 1,3-diketones or 1,3-diketoesters and the resultant bisalkenyl 1,3-diketones or 1,3-diketoesters were reacted with AlCl(3) at room temperature to furnish pyran core embedded derivatives in good to excellent yields.

• 出版日期2010-12-15