Comparison of Labial Minor Salivary Gland Biopsies from Childhood Sjogren Syndrome and Age-matched Controls

作者：Yokogawa Naoto; Lieberman Scott M^*; Alawi Faizan; Bout Tabaku Sharon; Guttenberg Marta; Sherry David D; Vivino Frederick B

来源：Journal of Rheumatology, 2014, 41(6): 1178-1182.

DOI：10.3899/jrheum.131511

• SJOGREN SYNDROME
• PEDIATRICS
• DIAGNOSIS
• MINOR SALIVARY GLANDS
• PATHOLOGY

Objective. To determine an appropriate focus score cutoff for childhood Sjogren syndrome (SS).
Methods. Labial salivary gland tissue from specimens from children with SS and age-matched controls was retrospectively identified and reviewed by a blinded oral pathologist.
Results. The presence of any focal sialadenitis (focus score > 0 foci/4 mm(2)) was common among childhood SS samples but present in only 1 of 8 control samples.
Conclusion. The presence of any focal lymphocytic sialadenitis in minor labial salivary gland tissue is suggestive of childhood SS and should be included in future childhood SS-specific diagnostic or classification criteria.

• 出版日期2014-6