Antibacterial Effect of (2E,2E)-4,4-Trisulfanediylbis(but-2-enoic acid) against Staphylococcus aureus

作者：Wu, Tao^*; Huang, Yina; Chen, Yijun; Zhang, Min^*

来源：PLos One, 2018, 13(5): e0197348.

DOI：10.1371/journal.pone.0197348

• MACERATED GARLIC EXTRACT
• ANTIMICROBIAL ACTIVITY
• CEDRUS-DEODARA
• ESSENTIAL OILS
• PINE NEEDLES
• ALLICIN
• DISRUPTION
• CELLS

A new highly active molecule, (2E, 2E)-4,4-trisulfanediylbis(but-2-enoic acid) (TSDB), was designed and synthesized through comparative molecular field analysis with the diallyl trisulfide structure of garlic. TSDB exerted a strong inhibitory effect against Staphylococcus aureus, with minimal inhibitory and minimal bactericidal concentrations of 16 and 128 mu g/mL, respectively. TSDB destructed the integrity of the S. aureus cell membrane but weakly damaged the bacterial cell wall. TSDB also increased the conductivity and protein expression in microbial broth but minimally influenced the level of extracellular alkaline phosphatase. TSDB could be a novel food preservative.

• 出版日期2018-5-24
• 单位天津科技大学