A CLCNKA polymorphism (rs10927887; p.Arg83Gly) previously linked to heart failure is associated with the estimated glomerular filtration rate in the RENASTUR cohort

作者：Tavira Beatriz; Gomez Juan; Ortega Francisco; Tranche Salvador; Diaz Corte Carmen; Alvarez Francisco; Ortiz Alberto; Santos Fernando; Sanchez Nino Maria D; Coto Eliecer^*

来源：Gene, 2013, 527(2): 670-672.

DOI：10.1016/j.gene.2013.06.055

• CLCNKA
• Gene polymorphisms
• Glomerular filtration
• Renal function

A total of 569 individuals aged 55-85 and Caucasian were genotyped for SNP rs10927887 in the K-a renal chloride channel gene (CLCNKA). The following variables were significantly associated with an estimated glomerular filtration rate of (eGFR) %26lt;60 ml/min./1.73 m(2): age, type 2 diabetes, total cholesterol, LDL-cholesterol, and the CLCNKA GG genotype (p = 0.03; OR = 1.65, 95% CI = 1.04-2.62). This novel finding could partly explain the reported greater risk of heart failure linked to the CLCNKA SNP, but requires confirmation on other populations.

• 出版日期2013-9-25