An Ireland-Claisen rearrangement/RCM based approach for the construction of the EF-ring of ciguatmdn 3C

作者：Nogoshi Keisuke; Domon Daisuke; Fujiwara Kenshu^*; Kawamura Natsumi; Katoono Ryo; Kawai Hidetoshi; Suzuki Takanori

来源：Tetrahedron Letters, 2013, 54(7): 676-680.

DOI：10.1016/j.tetlet.2012.12.001

• Natural product synthesis
• Fused cyclic ethers
• Ireland-Claisen rearrangement
• Ring closing olefin metathesis
• Stereoselective synthesis

The EF-ring of ciguatoxin 3C, a marine toxin from the dinoflagellate Gambierdiscus toxicus, was stereoselectively synthesized by iterative use of a cyclic ether formation process based on chirality-transferring Ireland-Claisen rearrangement and ring-closing olefin metathesis.

• 出版日期2013-2-13