Low-Dose, Low-Concentration Levobupivacaine Plus Fentanyl Selective Spinal Anesthesia for Knee Arthroscopy: A Dose Finding Study

作者：De Santiago Jesus^*; Santos Yglesias Javier; Giron Jorge; Jimenez Alejandro; Errando Carlos L

来源：Anesthesia and Analgesia, 2011, 112(2): 477-480.

DOI：10.1213/ANE.0b013e318202cd03

BACKGROUND: Selective sensory spinal anesthesia preserves lower limb motor function and thus facilitates postanesthesia care unit (PACU) bypass and reduces ambulation recovery time.
METHODS: We compared the ambulation time and PACU bypass rate after using 3 low-dose, low-concentration levobupivacaine-fentanyl spinal solutions (5, 4, and 3 mg + 10 mu g) in a double-blind study consisting of 90 patients (ASA physical status I and II) scheduled to undergo knee arthroscopy.
RESULTS: The 3-mg dose was halted because of a large number of inadequate blocks (50%). Twenty-three percent and 80% of patients from groups 5 mg and 4 mg, respectively, bypassed the PACU (P = 0001). Ambulation took place after 70 minutes (30-130 minutes) (median [range]) in group 5 mg and 45 minutes (23-120 minutes) in group 4 mg (P = 0006).
CONCLUSION: Four milligrams levobupivacaine plus 10 mu g fentanyl produced adequate surgical anesthesia with the shortest time to ambulation and the highest PACU bypass rate. (Anesth Analg 2011;112:477-80)

• 出版日期2011-2