New Alkaloids from Hippeastrum papilio (Ravenna) Van Scheepen

作者：Guo Ying; de Andrade Jean P; Pigni Natalia B; Torras Claveria Laura; Tallini Luciana R; Borges Warley de S; Viladomat Francesc; Nair Jerald J; Zuanazzi Jose A S; Bastida Jaume^*

来源：Helvetica Chimica Acta, 2016, 99(2): 143-147.

DOI：10.1002/hlca.201500188

• Alkaloids
• Hippeastrum papilio
• Homolycorine-type derivatives
• Hippapiline
• Papiline
• Haemanthamine
• 3-O-demethyl-3-O-(3-hydroxybutanoyl)-

A new phytochemical study of the indigenous Brazilian species Hippeastrum papilio is reported herein. Three novel Amaryllidaceae alkaloids were isolated, including hippapiline (1), papiline (2), and 3-O-demethyl-3-O-(3-hydroxybutanoyl)haemanthamine (3). Their structures were determined by physical and spectroscopic methods. In addition, the known alkaloids, haemanthamine (4), galanthamine (5), narwedine (6), 11-hydroxygalanthamine (7), apogalanthamine (8), and 9-O-demethyllycosinine B (9) were identified. The unusual cis-B/C-ring fusion for the new homolycorine representative hippapiline was ratified by NMR and CD spectroscopy.

• 出版日期2016-2