Novel ferrocenyl nitroxides: Synthesis, structures, electrochemistry and antioxidative activity

作者：Qiu Xiao; Zhao Hongli; Lan Minbo^*

来源：Journal of Organometallic Chemistry, 2009, 694(24): 3958-3964.

DOI：10.1016/j.jorganchem.2009.08.012

• Ferrocenyl nitroxides
• X-ray structure
• Antioxidative activity
• Electrochemistry

Novel ferrocenyl nitroxides 3-6 were prepared as models for studying the linkage structure-activity relationship. Single-crystal Xray structures of compounds 4 and 5 were determined and comparatively studied. The in vitro antioxidative activities (e.g. scavenging superoxide anion and hydroxide radical) of compounds 3-6 and 4-ferrocenamido-2,2,6,6-tetramethyl-piperidin-oxy (2) were evaluated. Compounds 3 and 5 exhibit high scavenging activities in low concentration. Results from electrochemistry and UV/V is spectroscopy show that the redox property and antioxidative activity are closely related to the structure of the linkage bridging ferrocene and cyclic nitroxide moieties. The results further indicate that the ferrocene moiety plays a principal role in antioxidation. The modi. cation of linkage was found to be able to decrease the ferrocene/ferrocenium potential and improve the antioxidative activity effectively.

• 出版日期2009-11-15
• 单位华东理工大学