The microbiome and hepatobiliary-pancreatic cancers

作者：Mima Kosuke; Nakagawa Shigeki; Sawayama Hiroshi; Ishimoto Takatsugu; Imai Katsunori; Iwatsuki Masaaki; Hashimoto Daisuke; Baba Yoshifumi; Yamashita Yo ichi; Yoshida Naoya; Chikamoto Akira; Baba Hideo^*

来源：Cancer Letters, 2017, 402: 9-15.

DOI：10.1016/j.canlet.2017.05.001

• Bacteria
• Cholangiocarcinoma
• Gut-liver axis
• Hepatocellular carcinoma
• Pancreatic adenocarcinoma

The human intestinal microbiome encompasses at least 100 trillion microorganisms that can influence host immunity and disease conditions, including cancer. Hepatobiliary and pancreatic cancers have been associated with poor prognosis owing to their high level of tumor invasiveness, distant metastasis, and resistance to conventional treatment options, such as chemotherapy. Accumulating evidence from animal models suggests that specific microbes and microbial dysbiosis can potentiate hepatobiliary-pancreatic tumor development by damaging DNA, activating oncogenic signaling pathways, and producing tumor-promoting metabolites. Emerging evidence suggests that the gut microbiota may influence not only the efficacy of cancer chemotherapies and novel targeted immunotherapies such as anti-CTIA4 and anti-CD274 therapies but also the occurrence of postoperative complications after hepatobiliary and pancreatic surgery, which have been associated with tumor recurrence and worse patient survival in hepatobiliary-pancreatic cancers. Hence, a better understanding of roles of the gut microbiota in the development and progression of hepatobiliary-pancreatic tumors may open opportunities to develop new prevention and treatment strategies for patients with hepatobiliary-pancreatic cancer through manipulating the gut microbiota by diet, lifestyle, antibiotics, and pro- and prebiotics.

• 出版日期2017-8-28