Antidepressant-like effect of trans-resveratrol: Involvement of serotonin and noradrenaline system

作者：Xu, Ying; Wang, Zhichao; You, Wenting; Zhang, Xiuhua; Li, Shan; Barish, Philip A.; Vernon, Matthew M.; Du, Xia; Li, Gaowen; Pan, Jianchun; Ogle, William O.^*

来源：European Neuropsychopharmacology, 2010, 20(6): 405-413.

DOI：10.1016/j.euroneuro.2010.02.013

• trans-Resveratrol
• Forced swimming
• Tail suspension
• Serotonin
• Noradrenaline
• MAO

The antidepressant-like effect of trans-resveratrol, a phenolic compound present in polygonum cuspidatum, was evaluated through behavioral and neurochemical methods. trans-Resveratrol (20, 40 and 80 mg/kg, via gavage) significantly decreased the immobility time in mouse models of despair tests, but did not influence locomotor activity. Two behavioral models and neurochemical assays suggested that trans-resveratrol produced a significant increase in serotonin and noradrenaline levels at 40 or 80 mg/kg in brain regions. In addition, trans-resveratrol dose dependently inhibited MAO-A activity. These findings indicate that the antidepressant-like effect of trans-resveratrol might be related to serotonergic and noradrenergic activation. Published by Elsevier B.V.

• 出版日期2010-6
• 单位北京市海淀医院; 温州医科大学