A spot test for detection of cobalt release - early experience and findings

作者：Thyssen Jacob P^*; Menne Torkil; Johansen Jeanne D; Liden Carola; Julander Anneli; Moller Per; Jellesen Morten S

来源：Contact Dermatitis, 2010, 63(2): 63-69.

DOI：10.1111/j.1600-0536.2010.01749.x

• allergy
• cobalt
• dermatitis
• screening
• spot test

Objectives: To present early findings with a newly developed cobalt spot test.
Methods and Results: A cobalt spot test based on disodium-1-nitroso-2-naphthol-3,6-disulfonate was able to identify cobalt release at 8.3 ppm. The test may also be used as a gel test if combined with an agar preparation. We found no false-positive reactions when testing metals and alloys known not to contain cobalt. However, one cobalt-containing alloy, which elicited cobalt dermatitis in cobalt-allergic patients, was negative upon cobalt gel testing.
Conclusions: The cobalt test detects amounts of cobalt release that approximate the elicitation concentration seen in cobalt-allergic patients. It may serve as a useful tool in dermatology offices and workplaces.

• 出版日期2010