科研之友
微信
新浪微博
Facebook
分享链接
摘要
The NZ white rabbit is the animal of choice for much experimental work due to its muscular frame and similar response to human diseases, and is one of the few mammals that have had their genome sequenced. However, continuum-level computational models of rabbit muscle detailing fibre architecture are limited in the literature, especially the triceps surae complex (gastrocnemius, plantaris and soleus), which has similar biomechanics and translatable findings to the human. This study presents a geometrical model of the rabbit triceps surae informed with diffusion-weighted imaging (DWI)-based fibres. Passive rabbit-specific material properties are estimated using known muscle deformation inferred from magnetic resonance imaging data and dorsiflexion force measured with a custom-built rabbit rig and transducer. Muscle shape prediction is evaluated against a second rabbit. This study revealed that the triceps surae steady-state force post-rigor is close to post-mortem for small deformations but increases by a fixed ratio as the deformation increases and can be used to evaluate the passive behaviour of muscle. DWI fibre orientation significantly influences shape and mechanics during simulated computational muscle contraction. The presented triceps surae force and material properties may be used to inform the constitutive behaviour of continuum rabbit muscle models used to investigate pathology and musculotendon treatments that may be translated to the human condition.
- 出版日期2017-10
