ARIDIA represses hepatocellular carcinoma cell proliferation and migration through IncRNA MVIH

作者：Cheng, Sheng; Wang, Lan^*; Deng, Chuan-Huai; Du, Shi-Chun; Han, Ze-Guang^*

来源：Biochemical and Biophysical Research Communications, 2017, 491(1): 178-182.

DOI：10.1016/j.bbrc.2017.07.072

• ARID1A
• SWI/SNF chromatin remodeling complex
• IncRNA
• Hepatocellular carcinoma
• MVIH

ARID1A, encoding the BAF250a subunit of SWI/SNF complex, has a high mutation frequency in numerous types of cancer. LncRNAs, a type of non-coding RNAs longer than 200 nucleotides, have been reported to interplay with SWI/SNF complex during cancer progression. However, whether the interaction between ARID1A and IncRNA affects hepatocellular carcinoma (HCC) still needs to be investigated. Here, we reveal that ARIDIA interacts with IncRNA MVIH through some region(s) or domain(s) including ARID domain and C-terminal ARIDIA protein binding domain. ARIDIA upregulates its downstream target CDKN1A and suppresses HCC cell proliferation and migration through inhibiting MVIH. Our data suggests that deficiency or loss of functional mutations of ARID1A in HCC cells might contribute to the increased activity of certain cancer-promoting IncRNAs.

• 出版日期2017-9-9
• 单位上海市闵行区中心医院; 上海交通大学