Antiviral effect of strictinin on influenza virus replication

作者：Saha Repon Kumer; Takahashi Tadanobu; Kurebayashi Yuuki; Fukushima Keijo; Minami Akira; Kinbara Noriaki; Ichitani Masaki; Sagesaka Yuko M; Suzuki Takashi^*

来源：Antiviral Research, 2010, 88(1): 10-18.

DOI：10.1016/j.antiviral.2010.06.008

• Strictinin
• Virus
• Influenza
• Parainfluenza
• Antiviral
• Viral entry

Strictinin, which is a member of the ellagitanin family of hydrolyzable tannins, prevented replication of human, duck and swine influenza A viruses (IAVs) in vitro at non-toxic concentrations. The addition of strictinin at the same time as IAV inoculation to MDCK cells inhibited viral replication in a dose-dependent manner. Strictinin showed 50% inhibitory concentrations for IAVs from 0.09 +/- 0.021 to 0.28 +/- 0.037 mu M (mean +/- S.E.M.) by the focus-forming assay. Treatment of MDCK cells with strictinin before and after viral inoculation resulted in no significant antiviral activity. Further studies showed that strictinin inhibited IAV-induced hemifusion. However, strictinin exhibited no inhibitory effect against receptor binding, sialidase activity. Strictinin also showed an antiviral effect on influenza B virus and human parainfluenza virus type-1 in vitro. The results indicate that strictinin is a useful antiviral agent.

• 出版日期2010-10