A Molecular Doorstop Ensures a Trickle through Translational Repression

作者：Brook Matthew; Smith Richard W P; Gray Nicola K^*

来源：Cell, 2012, 149(1): 13-15.

DOI：10.1016/j.cell.2012.03.010

Switching mRNA translation off and on is central to regulated gene expression, but what mechanisms moderate the extent of switch-off? Yao et al. describe how basal expression from interferon-gamma-induced transcripts is maintained during mRNA-specific translational repression. This antagonistic mechanism utilizes a truncated RNA-binding factor generated by a unique alternative polyadenylation event.

• 出版日期2012-3-30