Association of serum gamma-glutamyltransferase and premature coronary artery disease

作者：Sheikh M; Tajdini M; Shafiee A; Anvari M Sotoudeh; Jalali A; Poorhosseini H; Amirzadegan A^*

来源：Netherlands Heart Journal, 2017, 25(7-8): 439-445.

DOI：10.1007/s12471-017-0964-5

• Acute coronary syndrome
• Premature coronary artery disease
• Coronary angiography
• Gamma-glutamyltransferase

Background Serum gamma-glutamyltransferase (GGT) has been introduced as a predictive factor for cardiovascular disease. In this study, we investigated the association of serum GGT and premature coronary artery disease (CAD) in candidates for coronary angiography.
Methods In this cross-sectional study, we enrolled male subjects aged <= 45 years and female subjects <= 55 years who were candidates for elective coronary angiography due to typical chest pain or a positive non-invasive test. Baseline characteristics were recorded for all the participants and serum levels of blood glucose, lipid profile and GGT were measured. Patients were divided into CAD and non-CAD groups based on angiography for further comparisons.
Results From a total of 367 patients (age 45.1 +/- 6.1 years, 161 males [43.9%]), 176 (47.9%) patients had premature CAD. A high level of GGT was significantly associated with the presence of CAD (p < 0.001). A 10-unit increase in GGT could strongly predict the presence of premature coronary artery disease (OR: 13.34, 95% CI: 7.19-24.78; p < 0.001) after adjustment for confounders. The area under the receiver operating characteristic curve for GGT was 80.9% (range 76.5-85.3) and the sensitivity and specificity of GGT at a cut-point of 22.5 IU/l was 80.1% and 70.2%, respectively. Diagnostic accuracy of GGT was 74.9%. The positive predictive value and negative predictive value for GGT was 71.3 and 79.3, respectively.
Conclusion We observed that GGT levels in patients with typical chest pain or positive non-invasive tests could predict the presence of premature CAD in young patients.

• 出版日期2017-7