A population-based study of atopic disorders and inflammatory markers in childhood before psychotic experiences in adolescence

作者：Khandaker Golam M^*; Zammit Stanley; Lewis Glyn; Jones Peter B

来源：Schizophrenia Research, 2014, 152(1): 139-145.

DOI：10.1016/j.schres.2013.09.021

• Atopic disorders
• Asthma
• Eczema
• Childhood
• Adolescence
• Psychotic experiences
• Psychotic symptoms
• Schizophrenia
• Inflammatory markers
• IL-6
• CRP
• Cytokine
• Immunity
• Birth cohort
• Prospective study
• ALSPAC

Objective: Schizophrenia is associated with atopy and increased inflammatory markers. We report a population-based longitudinal study of the associations between childhood atopic disorders, subsequent serum inflammatory markers, interleukin 6 (IL-6) and C-reactive protein (CRP), and the risk of psychotic experiences (PEs).
Method: PEs were assessed at age 13 years (n = 6785). Presence of clinician-diagnosed atopic disorders (asthma and eczema) was determined from parent-completed questionnaires at age 10 years (n = 7814). Serum IL-6 and CRP were measured at age 9 years (n = 5076). Logistic regression examined the association between (1) atopy and PEs, (2) inflammatory markers and PEs, and (3) mediating effects of inflammatory markers on the atopy-PEs association. Linear regression examined the association between atopy and inflammatory markers. Age, gender, social class, ethnicity and body mass index were included as potential confounders.
Results: At age 10 years, about 14% of the sample was reported to have asthma, 12% eczema, and 7% both asthma and eczema. Compared with children with no atopy, risk of PEs at age 13 years was increased for all of these groups; adjusted odds ratios (95% CI) were, respectively, 1.39 (1.10-1.77), 1.33 (1.04-1.69), and 1.44 (1.06-1.94). Atopy was associated with increased serum IL-6 and CRP; however, this did not mediate association between atopy and PEs. Inflammatory markers were not associated with later PEs.
Conclusion: Childhood atopic disorders increase the risk of psychotic experiences in adolescence. Follow-up of these individuals will be useful to determine the effect of atopy and inflammation on different trajectories of early-life PEs.

• 出版日期2014-1