Nucleic Acids with a Six-Membered 'Carbohydrate' Mimic in the Backbone

作者：Herdewijn Piet^*

来源：Chemistry and Biodiversity, 2010, 7(1): 1-59.

DOI：10.1002/cbdv.200900185

Starting from pyranose nucleic acids, several series of modified nucleic acids with a six-membered carbohydrate moiety (mimic) have been synthesized and analyzed over a period of 20 years, and this work is summarized here. The process starts with structural and conformational considerations, followed by synthetic efforts and a structural analysis, and ends up with a biological confirmation of the concept, demonstrating that these modified nucleic acids represent very valuable tools in chemistry and biology.

• 出版日期2010