A case-control study of lower urinary-tract infections, associated antibiotics and the risk of developing prostate cancer using PCBaSe 3.0

作者：Russell Beth^*; Garmo Hans; Beckmann Kerri; Stettin Par; Adolfsson Jan; Van Hemelrijck Mieke

来源：PLos One, 2018, 13(4): e0195690.

DOI：10.1371/journal.pone.0195690

Objectives
To investigate the association between lower urinary-tract infections, their associated antibiotics and the subsequent risk of developing PCa.
Subjects/Patients (or materials) and methods
Using data from the Swedish PCBaSe 3.0, we performed a matched case-control study (8762 cases and 43806 controls). Conditional logistic regression analysis was used to assess the association between lower urinary-tract infections, related antibiotics and PCa, whilst adjusting for civil status, education, Charlson Comorbidity Index and time between lower urinary-tract infection and PCa diagnosis.
Results
It was found that lower urinary-tract infections did not affect PCa risk, however, having a lower urinary-tract infection or a first antibiotic prescription 6-12 months before PCa were both associated with an increased risk of PCa (OR: 1.50, 95% CI: 1.23-1.82 and 1.96, 1.71-2.25, respectively), as compared to men without lower urinary-tract infections. Compared to men with no prescriptions for antibiotics, men who were prescribed >10 antibiotics, were 15% less likely to develop PCa (OR: 0.85, 95% CI: 0.78-0.91).
Conclusion
PCa was not found to be associated with diagnosis of a urinary-tract infection or frequency, but was positively associated with short time since diagnoses of lower urinary-tract infection or receiving prescriptions for antibiotics. These observations can likely be explained by detection bias, which highlights the importance of data on the diagnostic work-up when studying potential risk factors for PCa.

• 出版日期2018-4-12