Aliskiren and losartan trial in non-diabetic chronic kidney disease

作者：Woo Keng Thye^*; Choong Hui Lin; Wong Kok Seng; Tan Han Kim; Foo Marjorie; Fook Chong Stephanie; Lee Evan J C; Anantharaman Vathsala; Lee Grace S L; Chan Choong Meng

来源：Journal of the Renin-Angiotensin-Aldosterone System, 2014, 15(4): 515-522.

DOI：10.1177/1470320313510584

• Aliskiren
• chronic kidney disease
• proteinuria
• side effects
• clinical trial

Introduction: This is a report of a clinical trial on the therapeutic efficacy and safety of combined aliskiren and losartan (an angiotensin II receptor blocker (ARB)) versus aliskiren alone and ARB alone in non-diabetic chronic kidney disease (CKD) over a 3-year period.
Materials and methods: This was a randomised trial in 155 patients with non-diabetic CKD comparing aliskiren (150 mg/day) (n=52) versus losartan (100 mg/day) (n=52) and the third group aliskiren (150 mg/day) combined with losartan (100 mg/day) (n=51). The trial utilised primary renal end points of eGFR <15 ml/min or end-stage renal failure.
Results: All three groups had significant reduction of proteinuria (p<0.001 for all). The changes in eGFR, total urinary protein from baseline to each year were not significantly different between the three therapeutic groups.
Conclusion: This study in non-diabetic CKD patients showed that combination therapy with aliskiren and ARB was as efficacious as aliskiren alone and ARB alone. There was one patient who developed a non-fatal stroke in the combined aliskiren and ARB group while the other two groups had none.

• 出版日期2014-12