An Adult Case of Anti-Myelin Oligodendrocyte Glycoprotein (MOG) Antibody-associated Multiphasic Acute Disseminated Encephalomyelitis at 33-year Intervals

作者：Numa Soichiro; Kasai Takashi^*; Kondo Takayuki; Kushimura Yukie; Kimura Ayaka; Takahashi Hisashi; Morita Kanako; Tanaka Akihiro; Noto Yu ichi; Ohara Tomoyuki; Nakagawa Masanori; Mizuno Toshiki

来源：Internal Medicine, 2016, 55(6): 699-702.

DOI：10.2169/internalmedicine.55.5727

• MOG
• ADEM
• optic neuritis
• adult

Acute disseminated encephalomyelitis (ADEM) followed by optic neuritis (ON) has been reported as a distinct phenotype associated with anti-myelin oligodendrocyte protein (MOG) antibody. We herein report the case of a 37-year-old woman who was diagnosed with ADEM at 4 years old of age and who subsequently developed ON followed by recurrent ADEM 33 years after the initial onset. A serum analysis showed anti-MOG antibody positivity. This phenotype has only previously been reported in pediatric cases. Neurologists thus need to be aware that the phenotype may occur in adult patients, in whom it may be assumed to be atypical multiple sclerosis.

• 出版日期2016