Novel Indole-Based Analogs of Melatonin: Synthesis and in Vitro Antioxidant Activity Studies

作者：Shirinzadeh Hanif; Eren Burcu; Gurer Orhan Hande; Suzen Sibel^*; Ozden Seckin

来源：Molecules, 2010, 15(4): 2187-2202.

DOI：10.3390/molecules15042187

• indole
• hydrazone
• hydrazide
• melatonin
• synthesis
• antioxidant activity

The aim of this study was to synthesize and examine possible in vitro antioxidant effects of indole-based melatonin analogue compounds. As a part of our ongoing study nineteen indole hydrazide/hydrazone derivatives were synthesized, characterized and their in vitro antioxidant activity was investigated by three different assays: by evaluating their reducing effect against oxidation of a redox sensitive fluorescent probe, by examining their protective effect against H(2)O(2)-induced membrane lipid peroxidation and by determining their inhibitory effect on AAPH-induced hemolysis of human erythrocytes. The results indicated significant strong antioxidant activity for most of the compounds, when compared to melatonin.

• 出版日期2010-4