New developments on the TNF alpha-mediated signalling pathways

作者：Sethu Swaminathan; Melendez Alirio J^*

来源：Bioscience Reports, 2011, 31(1): 63-76.

DOI：10.1042/BSR20100040

• apoptosis
• cell survival
• inflammation
• lipid
• nuclear factor kappa B (NF-kappa B)
• signal transduction
• TNF alpha (tumour necrosis factor alpha)

TNF alpha (tumour necrosis factor a) is an extensively studied pleiotropic cytokine associated with the pathogenesis of a variety of inflammatory diseases. It elicits a wide spectrum of cellular responses which mediates and regulates inflammation, immune response, cell survival, proliferation and apoptosis. TNF alpha initiates its responses by binding to its receptors. TNF alpha-induced effector responses are mediated by the actions and interactions among the various intracellular signalling mediators in the cell. TNF alpha induces both survival and apoptotic signal in a TRADD (TNF receptor-associated DD)-dependent and -independent way. The signals are further transduced via a variety of signalling mediators, including caspases, MAPKs (mitogen-activated protein kinases), phospholipid mediators and miRNA/miR (microRNA), whose roles in specific functional responses is not fully understood. Elucidating the complexity and cross talks among signalling mediators involved in the TNF alpha-mediated responses will certainly aid in the identification of molecular targets, which can potentially lead to the development of novel therapeutics to treat TNF alpha-associated disorders and in dampening inflammation.

• 出版日期2011-2