科研之友
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摘要
Type 2 diabetes is a major global health concern. Recent evidence suggests that inflammation may play a role in the development of this disease. Therefore, immune system markers could serve as prognostic biomarkers for diabetes. The aim of the study was to examine whether white blood cell (WBC) count could predict diabetes incidence in the general Chinese population during a 15-year follow-up. Data were collected in 1992 and again in 2007 from 687 individuals. Questionnaire, physical examination, and laboratory tests were performed using a standardized protocol. To assess the effects of baseline WBC count on the onset of diabetes, Cox's proportional hazards regression models were used to estimate hazard ratios, and the area under the receiver-operating curve assessed the discriminatory power of anthropometric measures for diabetes. Seventy-four individuals were diagnosed with diabetes during the 15-year follow-up period (incidence: 10.8 %). Time of onset was 11.2 +/- 3.8 years. Increased WBC count increased diabetes risk during the follow-up after adjusting for other potential risk factors (P = 0.041). The areas under the receiver-operating curves for WBC count did not significantly predict incident diabetes better than traditional risk factors such as body mass index (BMI) in the general population cohort both at 7-8-year (area under curve (AUC) = 0.06, 95 % CI -0.162-0.282, P = 0.597) and 15-year follow-up (AUC = 0.1, 95 % CI 0.006-0.205, P = 0.065). An increasing WBC count increases the risk of type 2 diabetes incidence. Yet, it was an inappropriate predictor of diabetes in a middle-aged Chinese population compared to traditional risk factors such as BMI.
- 出版日期2017-6
- 单位四川大学
