Association of STAT4 genetic polymorphisms with biliary atresia in Chinese patients

作者：Pei, Jiahao; Dong, Rui; Yang, Yifan; Zheng, Chao; Liu, Jia; Zheng, Shan^*

来源：International Journal of Clinical and Experimental Pathology, 2017, 10(3): 3451-3455.

• Biliary atresia
• gene polymorphism
• Han Chinese patients
• STAT4
• SNP rs7574865

Biliary atresia (BA) is a devastating disease of the liver characterized by progressive fibro-inflammatory obliteration in neonates. Without effective treatment, end stage of liver, will ultimately lead to die about 2 years old. STAT4 is a now known as a susceptibility gene for autoimmune diseases and a STAT4 minor allele may be associated with several liver diseases. A case-control study was done between 113 patients with BA and 133 healthy controls. The rs7574865 and rs8179673 single nucleotide polymorphisms (SNPs) and rs10168266 SNPs in the STAT4 gene were selected for genotyping. There was no significant difference in allele distribution between BA and controls (rs7574865, P = 0.6213, odds ratio [OR] = 1.098, 95% confidence interval [CI] = 0.758-1.589; rs8179673, P = 0.5702, OR = 0.898, 95% CI = 0.620-1.301; rs10168266, P = 0.9351, OR = 1.016, 95% CI = 0.699-1.477), and similar results were found for the genotype and haplotype frequencies of these STAT4 gene polymorphisms. Our results indicated that these STAT4 gene polymorphisms do not have a major role in the development of BA in Chinese children.

• 出版日期2017
• 单位复旦大学