A New Approach to the Synthesis of beta-Formyl-boron-dipyrromethenes

作者:Ye Jiahai*; Ye Wenfang; Xiao Chengtao; Chen Yu; Wang Guangpu; Zhang Wenchao
来源:Chinese Journal of Organic Chemistry, 2012, 32(8): 1503-1508.
DOI:10.6023/cjoc201204023

摘要

A series of beta-formyl-boron-dipyrromethenes (BODIPYs) 2 and beta-formyl-aza-BODIPYs 4 were synthesized from tetramethyl-BODIPYs 1 and tetraaryl-aza-BODIPYs 3 respectively via the Vilsmeier-Haack reaction using (COCl)(2) and DMF as the precursors efficiently. The Vilsmeier-Haack reaction was carried out smoothly under room temperature or 50 degrees C for BODIPYs or aza-BODIPYs respectively to give the beta-formyl products in good yield. The advantage of this new method is the using of commercially available chemical and the less pollution.