Association of BAFF and IL-17A with subphenotypes of primary Sjogren's syndrome

作者：Deng, Fengyuan; Chen, Juan^*; Zheng, Junfeng; Chen, Yan; Huang, Renliang; Yin, Junping; Gao, Xing; Lin, Qingyan; Huang, Chaoyang; Gao, Yushan; Yu, Xinhua; Liu, Zuguo^*

来源：International Journal of Rheumatic Diseases, 2016, 19(7): 715-720.

DOI：10.1111/1756-185X.12569

• B-cell activating factor
• interleukin-17A
• primary Sjogren's syndrome

Aim: Primary Sjogren's syndrome (pSS) is an autoimmune disease affecting exocrine glands. Both autoreactive T cells and B cells are involved in the development of pSS, but their exact contribution to the pathogenesis is not clear. Here, we aimed to investigate the association of B-cell activating factor (BAFF) and interleukin (IL)-17A with subphenotypes of pSS. @@@ Methods: Peripheral blood samples were collected from 31 pSS patients and 28 healthy controls. The serum levels of BAFF and IL-17A were quantified by sandwich ELISA. @@@ Results: The increased circulating BAFF levels are associated with higher immunoglobulin G (IgG) levels (P = 0.0167) and anti-Ro/SS antigen A autoantibody (P = 0.032), while the elevated circulating levels of IL-17A are associated with lower C3 levels (P = 0.0213) and higher focus score of salivary gland tissue (P = 0.002). @@@ Conclusion: Our results show that BAFF and IL-17A are associated with different subphenotypes of pSS, suggesting both humoral and cellular immune response are involved in the pathogenesis of pSS.

• 出版日期2016-7
• 单位厦门大学