Anti-NF155 chronic inflammatory demyelinating polyradiculoneuropathy strongly associates to HLA-DRB15

作者：Martinez Martinez Laura; Cinta Lleixa Ma; Boera Carnicero Gemma; Cortese Andrea; Devaux Jerome; Siles Ana; Rajabally Yusuf; Martinez Pineiro Alicia; Carvajal Alejandra; Pardo Julio; Delmont Emilien; Attarian Shahram; Diaz Manera Jordi; Callegari Ilaria; Marchioni Enrico; Franciotta Diego; Benedetti Luana; Lauria Guiseppe; de la Calle Martin Oscar; Juarez Candido; Illa Isabel; Querol Luis^*

来源：Journal of Neuroinflammation, 2017, 14(1): 224.

DOI：10.1186/s12974-017-0996-1

• CIDP
• Antibodies
• NF155
• HLA DRB1*15

Background: The aim of the research is to study the human leukocyte antigen (HLA) class II allele frequencies in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) associated with anti-neurofascin 155 (NF155) antibodies.
Methods: Thirteen anti-NF155+ and 35 anti-NF155 negative (anti-NF155neg) CIDP patients were included in a case-control study. The frequencies of the DRB1 HLA allele were analyzed in all patients while DQ frequencies were only studied in patients sharing the DRB1*15 allele. In silico HLA-peptide binding and NF155 antigenicity, predictions were performed to analyze overlap between presented peptides and antigenic regions.
Results: DRB1*15 alleles (DRB1*15: 01 and DRB1*15: 02) were present in 10 out of 13 anti-NF155+ CIDP patients and in only 5 out of 35 anti-NF155neg CIDP patients (77 vs 14%; OR = 20, CI = 4.035 to 99.13). DRB1*15 alleles appeared also in significantly higher proportions in anti-NF155+ CIDP than in normal population (77 vs 17%; OR = 16.9, CI = 4.434 to 57. 30). Seven anti-NF155+ CIDP patients (53%) and 5 anti-NF155neg CIDP patients had the DRB1*15: 01 allele (OR = 7, p = 0.009), while 3 anti-NF155+ CIDP patients and none of the anti-NF155neg CIDP patients had the DRB1*15: 02 allele (OR = 23.6, p = 0.016). In silico analysis of the NF155 peptides binding to DRB1*15 alleles showed significant overlap in the peptides presented by the 15: 01 and 15: 02 alleles, suggesting functional homology.
Conclusions: DRB1*15 alleles are the first strong risk factor associated to a CIDP subset, providing additional evidence that anti-NF155+ CIDP patients constitute a differentiated disease within the CIDP syndrome.

• 出版日期2017-11-16