ACTH protects against glucocorticoid-induced osteonecrosis of bone

作者：Zaidi Mone^*; Sun Li; Robinson Lisa J; Tourkova Irina L; Liu Li; Wang Yujuan; Zhu Ling Ling; Liu Xuan; Li Jianhua; Peng Yuanzhen; Yang Guozhe; Shi Xingming; Levine Alice; Iqbal Jameel; Yaroslavskiy Beatrice B; Isales Carlos; Blair Harry C

来源：Proceedings of the National Academy of Sciences, 2010, 107(19): 8782-8787.

DOI：10.1073/pnas.0912176107

• osteoporosis
• osteoclast
• osteoblast

We report that adrenocorticotropic hormone (ACTH) protects against osteonecrosis of the femoral head induced by depot methylprednisolone acetate (depomedrol). This therapeutic response likely arises from enhanced osteoblastic support and the stimulation of VEGF by ACTH; the latter is largely responsible for maintaining the. ne vascular network that surrounds highly remodeling bone. We suggest examining the efficacy of ACTH in preventing human osteonecrosis, a devastating complication of glucocorticoid therapy.

• 出版日期2010-5-11