A Protocol for NMR Analysis of the Enantiomeric Excess of Chiral Diols Using an Achiral Diboronic Acid Template

作者:Tickell David A; Lampard Emma V; Lowe John P; James Tony D*; Bull Steven D*
来源:Journal of Organic Chemistry, 2016, 81(15): 6795-6799.
DOI:10.1021/acs.joc.6b01005

摘要

A practically simple derivatization protocol for determining the enantiopurity of chiral diols by H-1 NMR spectroscopic analysis is described. Diols were treated with 0.5 equiv of 1,3-phenyldiboronic acid to afford mixtures of diastereomeric boronate esters whose homochiral/heterochiral ratios are an accurate reflection of the diol's enantiopurity.

  • 出版日期2016-8-5