Antibodies to MOG are transient in childhood acute disseminated encephalomyelitis

作者：Proebstel A K; Dornmair K; Bittner R; Sperl P; Jenne D; Magalhaes S; Villalobos A; Breithaupt C; Weissert R; Jacob U; Krumbholz M; Kuempfel T; Blaschek A; Stark W; Gaertner J; Pohl D; Rostasy K; Weber F; Forne I; Khademi M; Olsson T; Brilot F; Tantsis E; Dale R C; Wekerle H; Hohlfeld R; Banwell B; Bar Or A; Meinl E^*; Derfuss T

来源：Neurology, 2011, 77(6): 580-588.

DOI：10.1212/WNL.0b013e318228c0b1

Objective: To study the longitudinal dynamics of anti-myelin oligodendrocyte glycoprotein (MOG) autoantibodies in childhood demyelinating diseases.
Methods: We addressed the kinetics of anti-MOG immunoglobulins in a prospective study comprising 77 pediatric patients. This was supplemented by a cross-sectional study analyzing 126 pediatric patients with acute demyelination and 62 adult patients with multiple sclerosis (MS). MOG-transfected cells were used for detection of antibodies by flow cytometry.
Results: Twenty-five children who were anti-MOG immunoglobulin (Ig) positive at disease onset were followed for up to 5 years. Anti-MOG antibodies rapidly and continuously declined in all 16 monophasic patients with acute disseminated encephalomyelitis and in one patient with clinically isolated syndrome. In contrast, in 6 of 8 patients (75%) eventually diagnosed with childhood MS, the antibodies to MOG persisted with fluctuations showing a second increase during an observation period of up to 5 years. Antibodies to MOG were mainly IgG 1 and their binding was largely blocked by pathogenic anti-MOG antibodies derived from a spontaneous animal model of autoimmune encephalitis. The cross-sectional part of our study elaborated that anti-MOG Ig was present in about 25% of children with acute demyelination, but in none of the pediatric or adult controls. Sera from 4/62 (6%) adult patients with MS had anti-MOG IgG at low levels.
Conclusions: The persistence or disappearance of antibodies to MOG may have prognostic relevance for acute childhood demyelination. Neurology (R) 2011;77:580-588

• 出版日期2011-8