Association of the IL-10 polymorphisms and periodontitis: a meta-analysis

作者：Albuquerque C M^*; Cortinhas A J; Morinha F J; Leitao J C; Viegas C A; Bastos E M

来源：Molecular Biology Reports, 2012, 39(10): 9319-9329.

DOI：10.1007/s11033-012-1738-1

• Interleukin-10
• Meta-analysis
• Periodontitis
• Polymorphism

No clear consensus has been reached regarding the association of IL-10 polymorphisms and periodontitis. Therefore, we performed a meta-analysis of case-control studies and a systemic review in an effort to systematically summarize the existing knowledge. Studies were identified by searching PubMed database until December 2011. IL-10 -1082 (-1087) A %26gt; G, -819 (-824) C %26gt; T and -592 (-597) C %26gt; A polymorphisms were included in the present meta-analysis. We calculated the specific odds ratios along with their 95 % confidence intervals to compare the distribution of alleles and genotypes between cases and controls. An additive %26quot;per-allele%26quot; model (major allele vs. minor allele) was performed, and dominant and recessive models were also considered. The random-effects model was applied for the analysis. Cumulative analysis was also performed. Heterogeneity and publication bias were assessed. Nine case-control studies involving 841 periodontitis cases (644 chronic periodontitis and 197 aggressive periodontitis cases) and 748 controls were included. We found statistically significant association of IL-10 -819 (-824) C %26gt; T and IL-10 -592 (-597) C %26gt; A polymorphisms in Caucasians. The IL-10 -819 (-824) T and -592 (-597) A alleles may confer a relative increase in the risk for chronic periodontitis in Caucasians. Future studies may be important to reinforce these findings.

• 出版日期2012-10