Antifungal activities of diphenyl diselenide and ebselen against echinocandin-susceptible and -resistant strains of Candida parapsilosis

作者：Chassot Francieli^*; Venturini Tarcieli Pozzebon; Piasenti Fernanda Baldissera; Santurio Janio Morais; Estivalet Svidzinski Terezinha Inez; Alves Sydney Hartz

来源：New Microbiologica, 2016, 39(4): 301-303.

• Diphenyl diselenide
• ebselen
• echinocandin
• antifungal agents
• Candida parapsilosis

We evaluated the in vitro antifungal activity of diphenyl diselenide and ebselen against echinocandin-susceptible and -resistant strains of Candida parapsilosis using the broth microdilution method. Diphenyl diselenide (MIC range = 1-8 mu g/mL) and ebselen (MIC range = 0.25-4 mu g/mL) showed in vitro activity against echinocandin-susceptible isolates. However, ebselen also showed the highest antifungal activity against echinocandin-resistant strains (MIC range = 0.06-4 mu g/mL). This study demonstrated that the antifungal potential of diphenyl diselenide and ebselen deserves further investigation using in vivo experimental protocols.

• 出版日期2016-10