Multigram Scale Synthesis of A21, A New Antibiotic Equally Effective and Less Toxic than Amphotericin B

作者：David Flores Romero Jose; Rodriguez Lozada Josue; Lopez Ortiz Manuel; Magana Ricardo; Ortega Blake Ivan; Regla Ignacio^*; Fernandez Zertuche Mario^*

来源：Organic Process Research & Development, 2016, 20(8): 1529-1532.

DOI：10.1021/acs.oprd.6b00211

A21 (2) is a new polyene macrolide Amphotericin B amide antibiotic derived from amphotericin B AmB (1), which has been tested extensively on preclinical trials showing the same antimycotic effectiveness and increased margin of safety over AmB (1). We present the multigram scale synthesis, isolation, purity assessment by HPLC, and key aspects of its characterization by NMR studies of A21 (2).

• 出版日期2016-8