Antifungal Activity of Extracts and Prenylated Coumarins Isolated from Baccharis darwinii Hook & Arn. (Asteraceae)

作者：Kurdelas Rita R; Lima Beatriz; Tapia Alejandro; Egly Feresin Gabriela; Gonzalez Sierra Manuel; Victoria Rodriguez Maria; Zacchino Susana; Enriz Ricardo D; Freile Monica L^*

来源：Molecules, 2010, 15(7): 4898-4907.

DOI：10.3390/molecules15074898

• Baccharis darwinii
• Asteraceae
• prenylated coumarins
• auraptene
• antimicrobial activity

The petroleum ether extract of Baccharis darwinii showed activity against Cryptococcus neoformans and dermatophytes. Bioactivity- guided fractionation of Baccharis darwinii has resulted in the isolation of three coumarins: 5'-hydroxy aurapten (anisocoumarin H, 1), aurapten (7-geranyloxycoumarin, 2) and 5'-oxoaurapten (diversinin, 3). The structures of these compounds were characterized by spectroscopic methods. These compounds were evaluated for their antimicrobial activity against a panel of each, bacteria and fungi. Compound 3 showed the best activities against Microsporum gypseum, Trichophyton rubrum and Trichophyton mentagrophytes with MICs = 15.6 mu g/mL, followed by compound 1 whose MICs against the same fungi were 62.5 mu g/mL. In addition they showed fungicidal rather than fungistatic activity. Both compounds showed moderate activity (MICs = 125 mu g/mL) against Cryptococcus neoformans. This is the first report of the presence of compound 1 in B. darwinii.

• 出版日期2010-7