A Short and Efficient Total Synthesis of (+/-)-Ascofuranone

作者：Haga Yasushi; Tonoi Takayuki; Anbiru Yoshihide; Takahashi Yuki; Tamura Sayuri; Yamamoto Masaichi; Ifuku Shinsuke; Morimoto Minoru; Saimoto Hiroyuki^*

来源：Chemistry Letters, 2010, 39(6): 622-623.

DOI：10.1246/cl.2010.622

Ascofuranone is a potent inhibitor of trypanosome alternative oxidase. A short and efficient total synthesis of (+/-)-ascoffiranone was accomplished in only seven steps starting with geranyl acetate. The synthetic concept and methodology described in detail here provide a short and simple synthesis for ascofuranone and its derivatives.

• 出版日期2010-6-5