Amyrins from Protium heptaphyllum Reduce High-Fat Diet-Induced Obesity in Mice via Modulation of Enzymatic, Hormonal And Inflammatory Responses

作者：Martins Bezerra Carvalho Karine Maria; de Melo Tiago Sousa; de Melo Karina Moura; Gomes Quindere Ana Luiza; Bandeira de Oliveira Francisca Tuelly; Seraine Custodio Viana Ana Flavia; Gomes Nunes Paulo Iury; Quetz Josiane da Silva; Viana Daniel de Araujo; de Carvalho Almeida da Silva Armenio Andre; Havt Alexandre; da Cruz Fonseca Said Goncalves; Chaves Mariana Helena; Rao Vietla Satyanarayana; Santos Flavia Almeida^*

来源：Planta Medica, 2017, 83(3-4): 285-291.

DOI：10.1055/s-0042-114222

• Protium heptaphyllum
• Burseraceae
• alpha,beta-amyrin
• pentacyclic triterpene
• high-fat diet
• antiobesity

Obesity remains a global problem. In search of phytochemicals that have antiobesity potential, this study evaluated alpha,beta-amyrin, a triter-penoid mixture from Protium heptaphyllum, on high-fat diet-induced obesity in mice. Groups of mice (n = 8) were fed a normal diet or a high-fat diet, and were orally treated or not treated with either alpha,beta-amyrin(10 or 20mg/kg) or sibutramine (10mg/kg) for 15 weeks. Variables measured at termination were body weight, visceral fat accumulation, adipocyte surface area, peroxisome proliferator-activated receptor gamma, and lipoprotein lipase expressions in adipose tissue, the levels of plasma glucose and insulin, the satiety hormones ghrelin and leptin, the digestive enzymes amylase and lipase, and the inflammatory mediators TNF-alpha, interleukin-6, and MCP-1. Results showed that alpha,beta-amyrin treatment resulted in lower high-fat diet-induced increases in body weight, visceral fat content, adipocyte surface area, peroxisome proliferator-activated receptor gamma, and lipoprotein lipase expressions, and blood glucose and insulin levels. Additionally, the markedly elevated leptin and decreased ghrelin levels seen in the high-fat diet-fed control mice were significantly modulated by alpha,beta-amyrin treatment. Furthermore, alpha,beta-amyrin decreased serum TNF-alpha and MCP-1. These results suggest that alpha,beta-amyrin could be beneficial in reducing high-fat diet-induced obesity and associated disorders via modulation of enzymatic, hormonal, and inflammatory responses.

• 出版日期2017-2