Antinociceptive and anti-inflammatory activities of the essential oil of Nepeta crispa Willd. in experimental rat models

作者：Ali Taskina; Javan Mohammad^*; Sonboli Ali; Semnanian Saeed

来源：Natural Product Research, 2012, 26(16): 1529-1534.

DOI：10.1080/14786419.2011.565284

• Nepeta crispa
• antinociception
• anti-inflammation
• cineole
• nepetalactone
• rat

This study was conducted to evaluate the antinociceptive and anti-inflammatory activities of the essential oil of Nepeta crispa. The study was done using the tail-flick and formalin test pain models and the paw oedema model of inflammation. Male Wistar rats were used as the animal model. The essential oil dose-dependently produced analgesia in the acute pain models, including the tail-flick (p %26lt; 0.001) and the first phase of the formalin test (p %26lt; 0.01). In the late phase of the formalin test, as a model of chronic pain, the essential oil significantly reduced the pain-induced behaviour (p %26lt; 0.01). Nepeta crispa essential oil caused potent anti-inflammatory effects in the formalin-induced paw inflammation model and significantly reduced the paw oedema in all applied doses (p %26lt; 0.01). Its effects on pain in both the acute and chronic pain models and its anti-inflammatory effect suggest both central and peripheral mechanisms of action for the essential oil obtained from N. crispa.

• 出版日期2012