Dermal dendritic cells, but not Langerhans cells, are critical in murine single epicutaneous sensitization

作者：Lee Chih Hung; Chen Jau Shiuh; Chiu Hsien Ching; Hong Chien Hui; Liu Ching Yi; Ta Yng Cun; Clausen Bjorn E; Ho Ji Chen; Wang Li Fang^*

来源：Experimental Dermatology, 2015, 24(1): 67-69.

DOI：10.1111/exd.12583

• dendritic cell subset
• epicutaneous sensitization
• Th1/Th2

A murine repeated protein-patch model has been established to study epicutaneous sensitization in atopic dermatitis. This model has shown a predominant Th2 and a weak Th1 response in both BALB/c and C57BL/6 mice. However, Th responses induced in the repeated model are not consistent with the generally accepted theory that BALB/c and C57BL/6 mice are Th2 and Th1 prone and are representatives of human atopy and non-atopy, respectively. In this study, a single protein-patch model was established, which showed in addition to the Th2 response, a remarkable Th1 response in C57BL/6 mice, but not in BALB/c mice. Moreover, using muLangerin-DTR mice, we demonstrated that dermal dendritic cells, but not Langerhans cells, are critical in single epicutaneous sensitization in both strains of mice.

• 出版日期2015-1
• 单位长春大学