A Catalytic, Asymmetric Formal Synthesis of (+)-Hamigeran B

作者：Mukherjee Herschel; McDougal Nolan T; Virgil Scott C; Stoltz Brian M^*

来源：Organic Letters, 2011, 13(5): 825-827.

DOI：10.1021/ol102669z

A concise asymmetric, formal synthesis of (+)-hamigeran B is reported. A Pd-catalyzed, decarboxylative allylic alkylation, employing a trifluoromethylated derivative of t-BuPHOX, is utilized as the enantioselective step to form the critical quaternary carbon center in excellent yield and enantioselectivity. The product is converted in three steps to a late-stage intermediate previously used in the synthesis of hamigeran B.

• 出版日期2011-3-4