A simple method for calculating power based on a prior trial

作者:Borm George F*; Bloem Bastiaan R; Munneke Marten; Teerenstra Steven
来源:Journal of Clinical Epidemiology, 2010, 63(9): 992-997.
DOI:10.1016/j.jclinepi.2009.10.011

摘要

Objective: When an investigator wants to base the power of a planned clinical trial on the outcome of another trial, the latter study may not have been reported in sufficient detail to allow this For example, when the outcome is a change from baseline, the power calculation requires the standard deviation of the difference, and it frequently happens that only the standard deviations of the baseline and the follow-up measurements are reported Also when a complex analysis or an analysis with covariates is planned, the power calculation may be difficult or impossible The objective was to develop a method to determine the power of a trial, based on minimal information from a previous (reference) trial
Study Design and Setting: We investigated the power calculation for a range of statistical methods, including the t-test, analysis of covariance, analysis of variance, linear regression, logistic regression. Poisson regression, the Wilcoxon test, and the logrank test.
Results: A method to calculate the power of a trial solely based on the P-value or the confidence interval of the outcome of the reference study
Conclusion: A power calculation based on an earlier similar trial only requires its P-value.

  • 出版日期2010-9