The myths surrounding mild stimulation in vitro fertilization (IVF)

作者：Orvieto Raoul^*; Vanni Valeria Stella; Gleicher Norbert

来源：Reproductive Biology and Endocrinology, 2017, 15(1): 48.

DOI：10.1186/s12958-017-0266-1

• Ovarian stimulation
• Aneuploidy
• Cost-effectiveness
• Ovarian hyperstimulation syndrome (OHSS)
• In vitro fertilization (IVF)
• Pregnancy rates
• Live birth rates

So-called mild controlled ovarian hyperstimulation (mCOH) has in recent years increased in popularity, claiming to be safer and more patient-friendly, while also improving in vitro fertilization (IVF) outcomes. We here challenge the International Society for Mild Approaches in Assisted Reproduction (ISMAAR) definition of mild stimulation, and especially address four fundamental issues, where our review found conventional COH (cCOH) advantageous over mCOH. They are: prevalence of severe ovarian hyperstimulation syndrome (OHSS), oocyte/embryo quality, pregnancy/live birth rates, and cost. We conclude that an objective review of the literature does not support the routine utilization of mCOH in assisted reproduction.

• 出版日期2017-6-24