Preparation of 2,7-diamino-1,8-naphthyridine: A useful building block for supramolecular chemistry

作者：Park T; Mayer MF; Nakashima S; Zimmerman SC^*

来源：Synlett, 2005, (9): 1435-1436.

DOI：10.1055/s-2005-868507

• heterocycles
• nucleophilic aromatic substitution
• supramolecular systems
• hydrogen bond
• amine protecting group

A two-step conversion of 2-chloro-7-ainido-1,8-naplithyridine to 2.7-diamino-1,8-naphthyridine is described. The process, which involves a nucleophilic aromatic substitution reaction with 4-methoxybenzylamine and subsequent deprotection, can be carried out on a large scale.

• 出版日期2005-6-1