Attenuated mTOR Signaling and Enhanced Glucose Homeostasis by Dietary Supplementation with Lotus Seedpod Oligomeric Procyanidins in Streptozotocin (STZ)-Induced Diabetic Mice

作者：Li Xiaopeng; Sui Yong; Wu Qian; Xie Bijun; Sun Zhida

来源：Journal of Agricultural and Food Chemistry, 2017, 65(19): 3801-3810.

DOI：10.1021/acsjafc.7b00233

• lotus seed oligomeric procyanidins
• synbiotics
• mTOR
• glucose homeostasis
• type 2 diabetes

This study investigated the protective role Of lotus seedpod oligomeric procyanidins (LSOPC) and synbiotics (Bifidobacterium Bb-12 and xylo-oligosaccharide) against high fat and streptozotocin (STZ)-induced diabetes. Administration of LSOPC or synbiotics had no effect on blood,glucose in normal mice. Treatments with LSOPC for 12 weeks markedly reduced blood glucose, FFA, endotoxin, and GHbA1c and improved glucose homeostasis, lipid metabolism, and insulin levels. In addition, administration of LSOPC significantly teversed the increase of mTOR and p66(shc) in liver, skeletal muscle, and White adipose tissue (WAT). LSOPC significantly increased glucose uptake and glycolysis in liver, skeletal muscle, and WAT while improving heat generation in brown adipose tissue (BAT) and inhibiting gluconeogenesis and lipogenesis in liver. Furthermore, synbiotics strengthened the improving effect of LSOPC. These findings demonstrated that LSOPC and synbiotics may regulate glucose disposal in peripheral target tissues through the p66(shc)-mTOR signaling pathway.

• 出版日期2017-5-17
• 单位华中农业大学; 湖北工业大学; 湖北省农业科学院