Atopic dermatitis : pathophysiology update

作者：Taieb Alain^*

来源：Bulletin de l Academie Nationale de Medecine, 2012, 196(3): 621-629.

• DERMATITIS
• ATOPIC
• ASTHMA
• FILAGGRIN

Atopic dermatitis (AD) is very common in industrialized countries, where it affects 15 % to 30 % of children and 2 % to 10 % of adults. AD has a complex determinism, combining environmental influences and genetic predisposition, hitherto dominated by an immunological perspective, particularly after the discovery of associated high IgE serum levels. DA is a possible mode of onset of asthma, allergic rhinitis and food allergies, resulting in the poorly understood "atopic march". The discovery of mutations in the filaggrin gene, a key protein for stratum corneurn maturation, have refocused attention on the skin and operated a Copernican revolution in our understanding of this group of disorders. AD has become a prototype of inflammatory epithelial barrier diseases. The epidermal barrier has three major elements: the stratum corneum, which provides an air-liquid barrio; tight junctions in the granular layer (liquid-liquid barrier), and Langerhans cells that capture antigens ( immunological barrier). Better knowledge of the molecular events underlying epidermal barrier function and its dysfunction in AD should lead to ways of preventing and eventually curing this group of disorders.

• 出版日期2012-3