Duration of hypertension is associated with cognitive function: a cross-sectional study in Chinese adults

作者：Li Tuo; Bai Yu; Xiang Junwu; Wang Rui; Bai Jie; Tuo Xiping^*; Zhao Zhongxin

来源：Chinese Medical Journal, 2014, 127(11): 2105-2110.

DOI：10.3760/cma.j.issn.0366-6999.20132872

• cognition impairment
• hypertension duration
• mini-mental-state-examination
• clock-drawing-test
• epidemiology

Background Hypertension (HTN) is a very prevalent public health problem and as the population ages, cognitive impairment (Cl) is also going to be a public health burden. However, the relationship between hypertension duration and cognitive function declination worldwide is still unknown. The aim of the study was to investigate the effects of HTN duration on CI in Chinese population.
Methods At baseline, 1 386 HTN patients and 293 normotensive (NT) people were enrolled. The HTN patients were further divided into four subgroups (duration of HTN <6 years, 6-10 years, 11-20 years, and >20 years) according to the HTN duration and were screened for cognitive function with neuropsychological tests including mini-mental-state-examination (MMSE) and clock-drawing-test (CDT) in comparison with the NT group.
Results More HTN patients had Cl (45.3%) than NT subjects (30.4%), and increased with HTN duration (P <0.000 1). Compared with the scores of MMSE and CDT in the NT group, the declines were higher in the HTN patients (P <0.000 1), and in the four HTN subgroups, both MMSE and CDT scores fail when the HTN duration increased (P <0.05). Furthermore, in the HTN population without Cl, the trend in alteration of Cl was relatively mild but still existed (P <0.05).
Conclusion People with HTN are more likely to have Cl and the possibility and aggravation increases the prolongation of HTN duration, both in amnesic and nonamnesic function.

• 出版日期2014-6-5
• 单位天津市中医药研究院附属医院; 中国人民解放军第二军医大学; 中国人民解放军第二0八医院