APPROACHES TO THERAPY FOR PRIMARY MEDIASTINAL B-LARGE-CELL LYMPHOMA

作者：Tyurina N G^*; Vernyuk M A; Pavlova O A

来源：Gematologiya i Transfuziologiya, 2014, 59(2): 50-56.

• primary mediastinal B-large cell lymphoma
• MACOP-B
• mabtera
• radiotherapy
• anterosuperior mediastinal tumor
• autologous hemopoietic stem cell transplantation

Primary mediastinal (thymic) B-large-cell lymphoma (PMBLCL) is a clinical morphological variant of non-Hodgkin's lymphonnas. The tumor develops from thymic B-cells, is characterized by a peculiar clinical course and routes of dissemination. Intense local growth of the tumor, infiltration of the adjacent structures and thoracic organs cause the development of the vena cava superior syndrome and respiratory insufficiency in the majority of patients during the disease debut. Because of the absence of prospective clinical studies, optimal approaches to therapy have not been developed. The relationship between the treatment efficiency and initial polychemotherapy (PCT) dose intensity and rituximab use, efficiency of high-dose chemotherapy with transplantation of autologous hemopoietic stem cells (auto-HSCT) and radiotherapy are in the focus of studies. Therapy of PMBLCL requires a differentiated approach. More intense therapy at the early stages with high-dose chemotherapy and auto-BSCT should be used in cases with prognostically unfavorable factors at the debut of the disease and after attaining partial remission after induction PCT including rituximab.

• 出版日期2014-6