An effective one-pot conversion of acid chlorides to aldehydes and ketones

作者：Park Jae Kyo; Shin Won Kyu; An Duk Keun^*

来源：Tetrahedron Letters, 2013, 54(24): 3199-3203.

DOI：10.1016/j.tetlet.2013.04.041

• Diisobutylaluminum hydride (DIBALH)
• Morpholine amide
• Acid chloride
• Aldehyde
• Ketone

Aldehydes and ketones were synthesized from their respective acid chlorides via a one-pot protocol. Morpholine amide intermediates that were readily prepared by the aminolysis of various acid chlorides with diisobutyl(morpholino)aluminum smoothly reacted with the reducing agent LDBMA and the organolithium reagents under mild reaction conditions (0 degrees C), giving almost excellent product yields of up to 95%.

• 出版日期2013-6-12