Mss116p A DEAD-box protein facilitates RNA folding

作者：Sachsenmaier Nora; Waldsich Christina^*

来源：RNA Biology, 2013, 10(1): 71-82.

DOI：10.4161/rna.22492

• RNA folding
• DEAD-box proteins
• ribozyme
• intron
• RNA-protein interactions
• RNA helicase

RNA folding is an essential aspect underlying RNA-mediated cellular processes. Many RNAs, including large, multi-domain ribozymes, are capable of folding to the native, functional state without assistance of a protein cofactor in vitro. In the cell, trans-acting factors, such as proteins, are however known to modulate the structure and thus the fate of an RNA. DEAD-box proteins, including Mss116p, were recently found to assist folding of group I and group II introns in vitro and in vivo. The underlying mechanism(s) have been studied extensively to explore the contribution of ATP hydrolysis and duplex unwinding in helicase-stimulated intron splicing. Here we summarize the ongoing efforts to understand the novel role of DEAD-box proteins in RNA folding.

• 出版日期2013-1