A case of beta-catenin-positive hepatocellular adenoma with MR imaging sign of diffuse intratumoral fat deposition

作者：Ishii Masaya^*; Kazaoka Junichi; Fukushima Junichi; Gunji Mariko; Aoyama Toru; Fukusato Toshio; Sano Keiji; Kondo Fukuo; Takeshita Toru; Furui Shigeru; Akahane Masaaki

来源：Abdominal Imaging, 2015, 40(6): 1487-1491.

DOI：10.1007/s00261-014-0342-3

• beta-Catenin-positive hepatocellular adenoma
• Hepatocellular adenoma
• Diffuse intratumoral fat deposition
• Diffuse intratumoral steatosis

Hepatocellular adenoma (HCA) is a rare primary benign tumor of the liver, which occurs predominantly in young and middle-aged women. Recently, the subclassification of HCA was proposed by the Bordeaux group. Subsequently, characteristic radiological and clinical features have been revealed in each HCA subtype. According to the previous literature, diffuse intratumoral fat deposition is a very common finding in hepatocyte nuclear factor 1 alpha-negative HCA, but this finding has been reported in beta-catenin-positive HCA in the literature for only one case. In this case report, we report the second case of beta-catenin-positive HCA with MR imaging sign of diffuse intratumoral fat deposition, confirmed immunohistologically on the basis of a surgical specimen. In addition, our case showed hypovascularity and isointensity on the hepatobiliary phase which have been reported as characteristic findings in beta-catenin-positive HCA. Diffuse intratumoral fat deposition can be observed in beta-catenin-positive HCA, which has a greater probability of malignant transformation than other types of HCA.

• 出版日期2015-8